… , is a second-generation STS inhibitor developed in the early … STS inhibition in treating
hormone-dependent breast cancer. … Irosustat inhibited xenograft growth by 50%, STX213 reduced …

… , is a second-generation STS inhibitor developed in the early … STS inhibition in treating
hormonedependent breast cancer. … Irosustat inhibited xenograft growth by 50%, STX213 reduced …

… hormone-dependent cancers, including breast cancer. Therefore, … broad chemical classification
of steroid sulfatase inhibitors. The … Second generation inhibitor STX-213 showed longer …

… Enzyme steroid sulfatase (STS) is considered as a promising … ], found second-generation
dual-action compounds that inhibit STS … STX213 and STX1938 possess superior properties in …

… a first line therapy in metastatic and hormone-dependent breast cancer in … STX 213 is a
second generation STS inhibitor that showed an eight times stronger effect than STX 64 in vitro to …

… Steroid sulphatase inhibitor is another important route for … by modifying 667Coumate, such
as STX213, which has greater … for aromatase inhibition and has the same efficacy against STS…

… strategy to treat CRPC and improve second-generation antiandrogen therapy. … and STX
213 are new-generation STSis that can suppress hormone-dependent human breast cancer …

… in the etiology and maintenance of breast cancer is illustrated in the effectiveness of the …
the potential of STS inhibition as a therapeutic approach in breast cancers are also problematic. …

… We next attempted to inhibit this E 2 -induced increase in STS activity by treating HCT116 …
, tamoxifen is a first line therapy against hormone-dependent breast cancer. However, it has …

… While CRPC is currently considered incurable, the second-generation anti-… steroid
sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer …